November, 2012

This month we have added some very interesting nucleotide-related publications covering a wide range of topics including: Cancer, Infants, Memory, Sexual performance, Healthy Nutrition, Intestinal Health and Immunity.

If anyone has more to add please drop me an email on gnelson(at)nucleotides4health.org 

Thanks again to everyone who gets in touch, for whatever reason. Interaction and knowledge-sharing was always a big part of the idea behind Nucleotides for Health in the hope that more research and investigation is conducted into the subject. A list of the papers that have been added recently appear below:
 

Gastrointestinal Publications:

Bustamante SA, Sanches N, Crosier J, Miranda D, Andmark GC, Miller JS. Dietary Nucleotides: Effects on the Gastrointestinal System in Swine. J Nutr. 1994 Jan;124(1 Suppl):149S-156S.
 

Immunity Publications:

Jyonouchi H. Nucleotide actions on humoral immune responses. J Nutr. 1994 Jan;124(1 Suppl):138S-143S.

Vitiello L, Gorini S, Rosano G, la Sala A. Immunoregulation through extracellular, ATP (eATP), nucleotides. Blood. 2012 Jun 1.
 

Nutritional Publications:

Clayton P, Rowbotham J. How the Mid-Victorians Worked, Ate and Died. Int J Environ Res Public Health. 2009 March; 6(3): 1235-1253.

Rudolph FB. The biochemistry and physiology of nucleotides. J Nutr. 1994 Jan;124(1 Suppl):124S-127S.

Uauy R. Non-immune system responses to dietary nucleotides. J Nutr. 1994 Jan;124(1 Suppl):157S-159S.
 

Other Publications:

Bester AC, Roniger M, Oren YS, Im MM, Sarni D, Chaoat M, Bensimon A, Zamir G, Shewach DS, Kerem B. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell. 2011 Apr 29;145(3):435-46.

Chen TH et al. Effects of dietary nucleoside-nucleotide mixture on memory in aged and young memory deficient mice. Life Sci. 1996;59(21):PL325-30.

Chen TH et al. A Nucleoside-Nucleotide Mixture May Reduce Memory Deterioration in Old Senescence-Accelerated Mice. J Nutr. 2000;130:3085-3089.

Hupertan V, Neuzillet Y, Stücker O, Pons C, Leammel E, Lebrett T. Effects of nucleotides adenosine monophosphate and adenosine triphosphate in combination with L-arginine on male rabbit corpus cavernosum tissue. International Journal of Andrology. doi: 10.1111/j.1365-2605.2012.01290.

Sánchez CL, Cubero J, Sánchez J, Chanclón B, Rivero M, Rodríguez AB, Barriga C. The possible role of human milk nucleotides as sleep inducers. Nutr Neurosci. 2009 Feb;12(1):2-8.

Yamamoto S, Wang MF, Adjei AA, Ameho CK. Role of nucleosides and nucleotides in the immune system, gut reparation after injury, and brain function. Nutrition. 1997 Apr;13(4):372-4.

Added to the N4H Database 25/11/2012

A full list of papers can be found on our publications pages.
 

That’s all for this update. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

Aug/Sept 2011

Nucleotides – speculation on lifestyle-induced essentiality

In the latest issue of "NHD" – The Dietitians' Magazine (NHDmag.com) – Dr Robert Verkerk discusses the fact that nucleotides “considered by researchers in the field as only 'conditionally essential' until now” may actually be 'seminally important for good health' and takes us on a journey through some of the main landmarks in the story of discovery that leads to this powerful speculation.

Scientists are now speculating that there is a dietary and lifestyle-induced essentiality for nucleotides:

"There is now widespread recognition among scientists that dietary simplification associated with the industrialisation of the human food supply is contributing to increased incidence of preventable chronic, inflammatory diseases, which now place the greatest burden on healthcare systems the world over."

Dr Robert Verkerk and Dr Peter Koeppel conclude:

"We therefore speculate: Could it be that fundamental nutritional benefits associated with nucleotides, such as DNA repair, cancer risk reduction, and gastrointestinal and immune health, would be well served by consistently elevated intake of those invaluable DNA spare parts that appear to be otherwise in short supply? We propose that this requirement for supplementary nucleotides could be contemplated as a form of lifestyle-induced essentiality, as distinct from the more usually considered physiological essentiality."

To download and read the article in full please follow this link 
 

That’s all for this month. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

July 2011

In the latest issue of "Functional Sports Nutrition" – The magazine for personal trainers and sports professionals serious about sports nutrition (www.fsnmag.com) – Dr Peter Koeppel discusses the role of nucleotides in health and specifically in relation to immunity, recovery and improved response for athletes:

Nucleotides and immunity

"If the nucleotide supply is insufficient, the flu viruses will proliferate unhindered, which may lead to more severe symptoms and prolonged illness. Conversely, with enough nucleotides the infection can be quickly counteracted during its initial stages."

"Importantly, nucleotides do not stimulate innate or acquired immunity, but rather provide the resource for unhindered cell proliferation, gene expression, and response to special environmental and physical challenges. Their universal use and fundamental functionality and efficacy in every living organism make nucleotides a valuable management tool for many stress- and health-related conditions."

Dietary and supplemental nucleotides

"The problem is that foods rich in nucleotides are now rarely on our menu. Meat products from organs such as liver, kidney, intestines and lung are particularly rich sources of nucleotides, but are now rarely eaten."

Nucleotides for athletes: improved recovery and muscle-to-fat ratio

"Futhermore, the more quickly cells are resynthesised after workouts, the faster and better will be the recovery."

"Particularly, in phases of intensive training, an additional supply of nucleotides through dietary intake is important. Nucleotides are essential for muscle function in different ways: besides protein synthesis, they improve oxygen transport and reduce the effects of lesions in the intestinal tract and muscles." 

To download and read the article in full please follow this link 
 

That’s all for this month. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

April 2011

Dr Nick Read of the IBS Network (formerly the Gut Trust) has had to retract comments he made about IntestAid^®IB (www.probiohealthcare.com) in reference to its benefits regarding IBS symptoms.

He met, last month, with Dr Peter Koeppel the scientist who has done most of the development work on IntestAid^®IB. Dr Koeppel assured Dr Read that studies in experimental animals had shown that the nucleotides (the building blocks of DNA) in IntestAid^®IB are not only absorbed in the intestine but also restore the structure and function of the stressed intestine, and are now included in infant feeding formulas and enteral feeds. 

Professor Christine Dancey a founder of the IBS network was originally sceptical about nucleotides however after conducting a clinical study reported in GR 70 and GR 78 she changed her mind.

Professor Dancey said, in response to Dr Read's comments:

"Nick Read misrepresented our research in the following ways:

1. He omitted to mention that there was also a statistically significant improvement in ‘a feeling of incomplete evacuation’ or that when all the symptoms except constipation were examined, the differences were in the same direction, even though not all were significant.  
2. This was a double blind randomised placebo controlled study, so that neither us nor the participants knew which condition they were in. The findings of this study are just as robust as those in drug trials and indicate that Intestaid IB did, in fact, make modest improvements in the symptoms of IBS in the majority of patients."

Dr Read in the latest issue of the Gut Reaction magazine, says:

"I apologise for any misleading comments, but clearly more research is needed to substantiate Dr Dancey's findings. Herein lies the rub; research is costly and only the largest pharmaceutical companies can afford the sort of studies needed to establish a product. Mr Cameron’s Big Society is all about promoting initiatives in the community. I wonder if there is a clinical scientist with IBS somewhere with sufficient motivation to organise such a study. The IBS Network would help design it and advertise for volunteers."

Prof. Christine Dancey has kindly given N4H users permission to directly download and read the full presentation for her IBS clinical trial, presented at the 2007 CAM Expo. The powerpoint presentation "Treating people with IBS" can be downloaded here and the commentary that refers to the presentation can be downloaded here.

Prof. Dancey’s published clinical paper:

Dancey et al. Nucleotide supplementation: A randomised double blind placebo controlled trial of IntestAid^®IB in people with irritable bowel syndrome. Nutrition journal 2006, 5:16. 

can be accessed via the Nutritional journal site by clicking here.
 

That’s all for this week. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

March, 2011

This month we have added some short sections on Nucleotides and Infants, Nucleotides and Intestinal Health and Nucleotides and Immunity.

If anyone has more to add please drop me an email on gnelson(at)nucleotides4health.org .

Thanks again to everyone who gets in touch, for whatever reason. Interaction and knowledge-sharing was always a big part of the idea behind Nucleotides for Health in the hope that more research and investigation is conducted into the subject. A list of the papers that have been added in recent weeks appear below:
 

Gastrointestinal Publications:

Christofi, F. L. Purinergic receptors and gastrointestinal secretomotor function Purinergic Signalling (2008) 4:213-236

Kimura,Y., Turner, J. R., Braasch,D. A. and Buddington R. K., Lumenal adenosine and AMP rapidly increase glucose transport. Am J Physiol Gastrointest Liver Physiol 289: G1007-G1014, 2005
 

Nutritional Publications:

Evans M. E., Tian, J., Gu, L. H., Jones D. P., and Ziegler, T. R. Dietary Supplementation With Orotate and Uracil Increases Adaptive Growth of Jejunal Mucosa After Massive Small Bowel Resection in Rats. Journal of Parenteral and Enteral Nutrition, Vol. 29, No. 5, 315-321 (2005)

Michaelidoua A. and Steijns J. Nutritional and technological aspects of minor bioactive components in milk and whey: Growth factors, vitamins and nucleotides. International Dairy Journal, Volume 16, Issue 11, November 2006, Pages 1421-1426

Perez, M. J., Sanchez-Medina, F., Torres, M., Gil, A. and Suarez, A. Dietary Nucleotides Enhance the Liver Redox State and Protein Synthesis in Cirrhotic Rats. J. Nutr. 134: 2504-2508, 2004.

Rodríguez-Serrano F, Ríos A, Marchal JA, Caba O, Martí­nez-Amat A, Prados J, Melguizo C, Ortiz R, Perán M, Boulaiz H, Vélez C, Alvarez P, Aránega A. Differentiation of Intestinal Epithelial Cells Mediated by Cell Confluence and/or Exogenous Nucleoside Supplementation. Cells Tissues Organs. 2010 Jan 14.

Added to the N4H Database 19/02/2010

A full list of papers can be found on our publications pages.
 

That’s all for this week. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon