September 2019

The Sep/Oct 2019 issue of FSN Magazine (www.fsnmag.com), contains an article discussing the significance of recent US research revealing the importance of nucleotides in keeping cells young.

Why do cells age

“The study, recently published in the ‘Journal of Biological Chemistry’, focused on senescence, a natural biological process where cells permanently stop creating new cells. The researchers revealed that senescent cells stopped producing nucleotides, which are basically the building blocks of DNA, during the ageing process. When the cells failed to produce nucleotides, these cells aged.”

Nucleotides are essential in keeping cells young

Alireza Delfarah, lead researcher, explains: “The production of nucleotides is essential to keep cells young. It also means that if we could prevent cells from losing nucleotide synthesis, they might age more slowly”

The importance of nucleotide supplementation 

According to Dr Peter Koeppel, pioneering expert on dietary nucleotides: “Diets that contain adequate amounts of nucleotides can compensate for the lower internal production of nucleotides by the cell, and restore its function. This is how dietary nucleotides can support the process of keeping cells healthy as we age. Unfortunately, only ‘true’ paleo diets, which include offal meats, can provide all the dietary nucleotides needed. This means people with nucleotide poor diets, heavy stress loads (e.g. athletes), or chronic and acute diseases, would be well advised to supplement their nucleotide intake, with readily digestible, purified nucleotides."

To download and read the article in full please follow this link 

The paper that this research quotes, has been added to our database this month and can be found here
 

That’s all for this month. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

September, 2019

This month we have added some very interesting nucleotide-related publications covering a wide range of topics including: Healthy Immunity, Digestive Health and Healthy Reproduction.

If anyone has more to add please drop me an email at info(at)nucleotides4health.org 

Thanks once again to everyone who gets in touch, for whatever reason. Interaction and knowledge-sharing was always a big part of the idea behind Nucleotides for Health in the hope that more research and investigation is conducted into the subject. A list of the papers that have recently been added to our database appear below:
 

Immunity Publications:

Nagafuchi S, Totsuka M, Hachimura S, Goto M, Takahashi T, Yajima T, Kuwata T, Kaminogawa S. Dietary nucleotides increase the mucosal IgA response and the secretion of transforming growth factor beta from intestinal epithelial cells in mice. Cytotechnology. 2002 Nov;40 1-3):49-58.

Other Publications:

Delfarah A, Parish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA. Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells. J. Biol. Chem. 2019; 294(27), 10564-10578.

Added to the N4H Database 18/09/2019

A full list of papers can be found on our publications pages.
 

That’s all for this update. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

June 2018

In the May/Jun 2018 issue of Functional Sports Nutrition (FSN) Magazine (www.fsnmag.com), Dr Peter Koeppel explores the contribution of nucleotides to the body’s production of ATP in an in-depth article: “An Energetic View of Nucleotides”.

All machines need fuel

“Our body is a finely tuned machine and like all machines, it needs fuel. Our ability to run, bicycle, ski, swim, and row depends on the capacity of the body to extract energy from ingested food. The more efficiently the body can extract nutrients from food, the more energy it has at its disposal for the daily activities. This article shows you which organs, cells and organelles are involved in the energy generation and how nucleotides are involved in these processes.”

The importance of dietary nucleotide supplementation

“It has been shown that the number of both red blood cells and haemoglobin is increased by supplementation of dietary nucleotides. During heavy physical exertion, with nucleotide supplementation the cells can stay longer in an aerobic state and are therefore able to produce more energy.”

To download and read the article in full please follow this link 
 

That’s all for this month. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

June, 2018

This month we have added some very interesting nucleotide-related publications covering a wide range of topics including: Clinical Applications for Nucleotides, Immune Healthy, Digestive Health, Infant Health, Healthy Nutrition and Cancer Chromosomal Instability (CIN).

If anyone has more to add please drop me an email at info(at)nucleotides4health.org 

Thanks once again to everyone who gets in touch, for whatever reason. Interaction and knowledge-sharing was always a big part of the idea behind Nucleotides for Health in the hope that more research and investigation is conducted into the subject. A list of the papers that have recently been added to our database appear below:
 

Gastrointestinal Publications:

Hess JR., Greenberg NA. The role of nucleotides in the immune and gastrointestinal systems: potential clinical applications. Nutr Clin Pract. 2012 Apr; 27(2):281-94.

Immunity Publications:

Hess JR., Greenberg NA. The role of nucleotides in the immune and gastrointestinal systems: potential clinical applications. Nutr Clin Pract. 2012 Apr; 27(2):281-94.

Schaller JP, Buck RH, Rueda R. Ribonucleotides: conditionally essential nutrients shown to enhance immune function and reduce diarrheal disease in infants. Seminars in Fetal & Neonatal Med. 2007 Feb; 12(1):35-44.

Other Publications:

Burrell R, et al. Replication stress links structural and numerical cancer chromosomal instability. Nature 494, 492-496, February 28, 2013.

Added to the N4H Database 27/06/2018

A full list of papers can be found on our publications pages.
 

That’s all for this update. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon