This area of our website is for those visitors who want to keep up-to-date with all the latest nucleotide related developments. Including news on the latest scientific papers and research publications as they are released it will also keep you in the know about worldwide events, exhibitions and seminars relating to the world of Nucleotides.

For returning visitors this section acts as a very handy overview of the updates and new additions to our site, To make sure you don’t miss a thing!

We are always on the lookout to keep the site up-to-date but we cannot be aware of everything that’s out there so we also rely heavily on your help to point us in the right direction.

If anyone knows of any papers or published works that they think deserve inclusion in our collection please get in touch. Submit the link for approval via the contact area of our site and we'll give you a mention here.
 

Mar/Apr 2022

Ingredient Spotlight: Nucleotides

Nucleotides feature as the guest in the “Ingredient Spotlight” feature of the latest issue of “FSN” – Functional Sports Nutrition Magazine (www.fsnmag.com).

The article discusses what nucleotides are, how they are the one type of nutrient that is common to some of the most essential functions of the body, the body’s wide-ranging demand for them and their relevance to the immune system in todays ongoing/post Covid world. It explores the move away from nucleotide rich foods in modern or restricted diets, and discusses and informs the cases for nucleotide ‘conditional’ essentiality and the need for dietary nucleotide supplementation.

Discussing the dietary and lifestyle-induced essentiality for nucleotides:

"When we consider nutrients, what normally comes to mind are the macros, proteins, fats, and sugar, or the micro-nutrients, vitamins, minerals and trace elements, and there are RDAs for most of the nutrients in these two groups. Since nucleotides are also a foundation for the effects of many micro- and macro-nutrients, they should really be considered as a crucial micronutrient class. Despite this, nucleotides are still not included in nutritional recommendations."

The article concludes:

"Poor nucleotide reserves lead to poor DNA expression, poor protein synthesis etc… These are situations where a therapist needs to consider adding balanced, purified nucleotides (which are predominantly of the pyrimidine type), to their patient supplement protocol."

To download and read the article in full please follow this link 
 

That’s all for this month. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

March, 2022

This month we have added some very interesting nucleotide-related publications covering a wide range of topics including: Digestion, Immunity, Digestive Health, Infants, Infant Formula, Healthy Nutrition, Resistance Exercise Stress and Performance Enhancement.

If anyone has more to add please drop me an email at info(at)nucleotides4health.org 

Thanks once again to everyone who gets in touch, for whatever reason. Interaction and knowledge-sharing was always a big part of the idea behind Nucleotides for Health in the hope that more research and investigation is conducted into the subject. A list of the papers that have recently been added to our database appear below:
 

Gastrointestinal Publications:

Correa F, Luise D, Archetti I, Bosi P, Trevisi P. Investigation of Early Supplementation of Nucleotides on the Intestinal Maturation of Weaned Piglets. Animals (Basel). 2021 May 21; 11(6): 1489.

Immunity Publications:

Sterczala, AJ et al. The physiological effects of nucleotide supplementation on resistance exercise stress in men and women. J Strength Cond Res. 2016 Feb; 30(2):569-78.

Nutritional Publications:

Wang L, Mu S, Xu X, Shi Z , Shen L. Effects of dietary nucleotide supplementation on growth in infants: a meta-analysis of randomized controlled trials. Eur J Nutr. 2019 Apr; 58(3): 1213-1221.

Other Publications:

Wang  L, Liu  J, Lv H, Zhang  X, Shen L. Effects of nucleotides supplementation of infant formulas on plasma and erythrocyte fatty acid composition: A meta-analysis. PLoS One. 2015 Jun 23; 10(6): e0127758.

Xu M, Liang R, Guo Q, Wang S, Zhao M, Zhang Z, Wang J, Li Y. Dietary nucleotides extend the life span in Sprague-Dawley rats. J Nutr Health & Ageing. 2013 Mar; 17(3): 223-9.

Added to the N4H Database 16/03/2022

A full list of papers can be found on our publications pages.
 

That’s all for this update. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

October 2021

An article by Dr Peter Koeppel (immunologist and nucleotide supplementation pioneer) in the October 2021 issue of InFocus Magazine (www.targetpublishing.com) exploring the importance of nucleotides in supporting a strong immune response and examining their role when it comes to vaccinations.

The Immune Response to Infection

“Only if too many microorganisms have penetrated, for example, through a wound, or if the immune system is weakened, can the pathogen spread in the body and cause an infection. At that point, the immune system reacts by producing various substances or cells against the invading microorganisms and finally destroys them. Macrophages migrate to the site of infection and begin to render the microorganisms harmless. They express some parts of the pathogens on their surface and thus activate the specific immune system. Specific B and T cells are newly formed, which release substances that kill the pathogens or form antibodies.”

“Antibodies are important components of the immune system. They mark and inactivate microorganisms and make them more recognisable to the immune cells. A particularly important component of the innate immune system are the so-called natural killer cells. They are specialised in recognising and destroying, especially virus-infected body cells. This combined defence force usually succeeds in destroying the invading microorganisms.”

Dietary and supplemental nucleotides

"A sufficient supply of nucleotides ensures optimal functioning of the immune defence, even against infections.”

“More defence cells are produced, and the antibody production also develops more effectively. Various publications demonstrate the positive effect of orally administered nucleotides on the immune system and their potential in bacterial and viral infections. Additional nucleotides are considered necessary for various physiological stresses, including growth and development, recovery from injury, infection, and certain disease states.”

Effect of nucleotides on vaccination

"An important step in immune defence is the formation of antibodies. In a trial, a normal vaccination was administered in the control group. The experimental group received for 60 days orally given nucleotides. The supplementation was started 14 days prior to vaccination up to day 60. The results of this experiment clearly show the effect of nucleotides on vaccination; even the first immune response is significantly higher than the one in the control. The titres are more than three times higher, which means that even at this stage, protection against infection is highly effective, whereas in the control, without nucleotides, protection is very weak" 

To download and read the article in full please follow this link 
 

That’s all for this month. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon
 

October, 2021

This month we have added some very interesting nucleotide-related publications covering a wide range of topics including: Immune Response, Digestive Health, Healthy Nutrition and Immune Function After Exercise.

If anyone has more to add please drop me an email at info(at)nucleotides4health.org 

Thanks once again to everyone who gets in touch, for whatever reason. Interaction and knowledge-sharing was always a big part of the idea behind Nucleotides for Health in the hope that more research and investigation is conducted into the subject. A list of the papers that have recently been added to our database appear below:
 

Gastrointestinal Publications:

Gao L, Xie C, Liang X, Li Z, Li B, Wu X, Yin Y. Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs. Anim Nutr. 2021 Mar; 7(1): 84-93.

Immunity Publications:

Ostojic SM, Obrenovic M. Sublingual nucleotides and immune response to exercise. Journal of the International Society of Sports Nutrition 2012; 9: 31.

Other Publications:

Abbaslou Y, Zahmatkesh D, Mahjoubi E, Yazdi MH, Beiranvand H, Gorjidooz M. Nucleotide Supplementation to Whole Milk Has Beneficial Effects on Post-Weaning Holstein Calf Performance. Animals (Basel). 2021 Jan 18; 11(1): 218.

Added to the N4H Database 20/10/2021

A full list of papers can be found on our publications pages.
 

That’s all for this update. Once again, if anyone else has knowledge of anything nucleotide-related that you feel should be mentioned on these pages please don’t hesitate to get in touch via our contact section.

Until then, regards - Gordon